Recombinant Human Epidermal Growth Factor (rh-EGF)

Mature human epidermal growth factor (HGF) is a low molecular weight single-chain polypeptide composed of 53 amino acids, with a molecular weight of approximately 6.2 kDa. It contains 6 cysteines in the molecule and forms 3 pairs of disulfide bonds in the chain. It is stable to acid, alkali, and heat, and can resist degradation of trypsin, chymotrypsin, and pepsin. It is one of the most stable protein polypeptides. HGF can perform a variety of biological functions by binding to the EGF receptor (EGFR) that is specific to the cell surface. It can be used to treat surgical trauma, skin ulcers, gastrointestinal ulcers, corneal damage, tissue repair, etc.

HGF can automatically combine with EGFR in the cell membrane near the wound, activate protein kinase, accelerate DNA, RNA, and protein synthesis, promote and regulate the growth and enlargement of epidermal cells, quickly heal the wound and repair the skin tissue. Therefore, adding HGF to cosmetics has the function of eliminating blemishes, acne, and acne. HGF also has a protective effect on normal skin, mainly delaying aging, increasing the elasticity and radiance of the skin.

Recombinant human epidermal growth factor (RH EGF) was expressed by extracellular secretion. The amino acid sequence and molecular structure were compatible with natural HGF and it had biological activity.

Biological Activity: Fully biologically active compared to standard. The ED50 determined by a cell proliferation assay using murine Balb / c 3T3 cells is less than 0.1 ng/ml, corresponding to a specific activity of> 1.0 x 107 IU / mg.

Application: research, laboratory, or other evaluation purposes. NOT FOR HUMAN USE.

GG stability amplifier; storage conditions:

Samples are stable for up to twelve months from the date of receipt between -20 ℃ and -80 ℃
Store in sterile conditions between -20 ℃ and -80 ℃. It is recommended to take aliquots of the protein for optimal storage. Avoid repeated freeze-thaw cycles.

Advancing frontiers:

Partial renal coverage after EVAR with adrenal fixation does not appear to be associated with early renal failure.

Author: Taneva Gergana T GT, Valdivia Andrés Reyes AR, Pitoulias Georgios A GA, El Amrani Mehdi M, Donas Konstantinos P KP, Guaita Julia Ocaña JO

Magazine: Ann Vasc Surg 2019-10-18 DOI: 10.1002 / smll.201802403

Summary: + Efforts to achieve optimal sealing during endovascular aortic aneurysm repair (EVAR) can result in partial coverage of the lower renal artery and, in some cases, even occlusion.

Regulatory cytokines prescribe the outcome of inflammation in the PEX production process.

Author: Sarenac Vulovic Tatjana T, Pavlovic Sladjana S, Lutovac Mitar M, Zdravkovic Vladimir V, Sreckovic Suncica S

Magazine: J Chin Med Assoc 2019-10-14 DOI: 10.1002 / small.201802403

Abstract: + The objective of this study is to reveal the participation of different regulatory cytokines in the pseudoexfoliation process (PEX).

Development of a new genetic signature in Helicobacter pylori-infected patients without gastric cancer

Author: Lv Xuemei X, Zhao Yanyun Y, Zhang Liwen L, Zhou Shuqi S, Zhang Bing B, Zhang Qiang Q, Jiang Longyang L, Li Xueping X, Wu Huizhe H

Magazine: J. Cell. Biochem. 10/21/2019 DOI: 10.1002/smell.201802403

Summary: + Stomach cancer (GC) is one of the deadliest cancers in the world.

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