lipofuscinoses neuronal ceroid (NCLs) is the most common neurodegenerative disorder-onset period marked by autosomal recessive inheritance, epileptic seizures, progressive psychomotor damage, visual failure, and early death. At least seven subtypes of NCLs time-onset have been identified from which the final form of infantile-onset (LINCLs) is genetically most heterogeneous with four genes that underlie identified.
A variant form of LINCL (vLINCL) present in patients Turkey has been regarded as a clinical entity and different genetic (CLN7). However, we have recently demonstrated that mutations in the gene CLN8 account for a subset of Turkey vLINCL. Towards identifying genes CLN7 us here filtered NCL loci known homozygosity in a family of nine Turkish vLINCL.
This locus is issued in seven families who may represent the ‘true’ Turkish vLINCL. In two families, we identified two novel homozygous mutation in the gene CLN6: base substitution intronic (c.542 + 5G> T) affects splicing of the transcript and nonsense mutation (c.663C> G) creates a stop codon at Tyrosine 221. These data indicate that CLN6 mutations, other than those of CLN8, should be considered as a diagnostic alternative in patients Turkey vLINCL. The genetic background of the ‘true’ Turkish vLINCL, CLN7, still to be defined.
 EDTA, disodium salt, dihydrate |
|
EB0185 |
Bio Basic |
500g |
EUR 84.01 |
|
|
) Tartaric acid (disodium dihydrate) |
|
HY-D0850 |
MedChemExpress |
500mg |
EUR 129.6 |
 Chromotropic Acid Disodium Salt Dihydrate |
|
20-abx186412 |
Abbexa |
|
|
|
|
 a-Ketoglutaric acid, disodium salt dihydrate |
|
KD0289 |
Bio Basic |
100g |
EUR 87.14 |
|
|
 EDTA, Disodium Dihydrate Salt Ultra Pure Grade |
|
20-147 |
Genesee Scientific |
500g/Unit |
EUR 366 |
 EDTA calcium disodium salt dihydrate, BP, Ph. Eur., USP grade |
|
GE8581-1KG |
Glentham Life Sciences |
1 kg |
EUR 241.2 |
EDTA calcium disodium salt dihydrate, BP, Ph. Eur., USP grade |
|
GE8581-250G |
Glentham Life Sciences |
250 g |
EUR 103.2 |
EDTA calcium disodium salt dihydrate, BP, Ph. Eur., USP grade |
|
GE8581-500G |
Glentham Life Sciences |
500 g |
EUR 151.2 |
 Azithromycin dihydrate |
|
A024-25MG |
TOKU-E |
25 mg |
EUR 279.6 |
 Quercetin dihydrate |
|
A2552-100 |
ApexBio |
100 mg |
EUR 324 |
|
Description: Quercetin Dihydrate is the dihydrate preparation of Quercetin, a ubiquitous natural flavonoid with antiproliferative properties. Quercetin is described to inhibit PLA2 and PI 3-kinase (IC50 = 3.8 microM), blocking the ATP binding site of this kinase and i |
Quercetin dihydrate |
|
A2552-25 |
ApexBio |
25 mg |
EUR 150 |
|
Description: Quercetin Dihydrate is the dihydrate preparation of Quercetin, a ubiquitous natural flavonoid with antiproliferative properties. Quercetin is described to inhibit PLA2 and PI 3-kinase (IC50 = 3.8 microM), blocking the ATP binding site of this kinase and i |
Quercetin dihydrate |
|
A2552-5.1 |
ApexBio |
10 mM (in 1mL DMSO) |
EUR 157.2 |
|
Description: Quercetin Dihydrate is the dihydrate preparation of Quercetin, a ubiquitous natural flavonoid with antiproliferative properties. Quercetin is described to inhibit PLA2 and PI 3-kinase (IC50 = 3.8 microM), blocking the ATP binding site of this kinase and i |
 Alvimopan dihydrate |
|
A3163-10 |
ApexBio |
10 mg |
EUR 512.4 |
|
Description: Alvimopan dihydrate is a selective antagonist of opioid receptor with IC50 value of 1.7 nM.Opioid receptor is a G protein-coupled receptor with opioids as ligands. |
Alvimopan dihydrate |
|
A3163-5 |
ApexBio |
5 mg |
EUR 343.2 |
|
Description: Alvimopan dihydrate is a selective antagonist of opioid receptor with IC50 value of 1.7 nM.Opioid receptor is a G protein-coupled receptor with opioids as ligands. |
Alvimopan dihydrate |
|
A3163-5.1 |
ApexBio |
10 mM (in 1mL DMSO) |
EUR 397.2 |
|
Description: Alvimopan dihydrate is a selective antagonist of opioid receptor with IC50 value of 1.7 nM.Opioid receptor is a G protein-coupled receptor with opioids as ligands. |
Alvimopan dihydrate |
|
A3163-50 |
ApexBio |
50 mg |
EUR 1399.2 |
|
Description: Alvimopan dihydrate is a selective antagonist of opioid receptor with IC50 value of 1.7 nM.Opioid receptor is a G protein-coupled receptor with opioids as ligands. |
 Cidofovir dihydrate |
|
B1238-10 |
ApexBio |
10 mg |
EUR 129.6 |
|
Description: Cidofovir dehydrate is an injectable antiviral medication for the treatment of cytomegalovirus (CMV) retinitis, which suppresses virus replication by selective inhibition of viral DNA synthesis. |
Cidofovir dihydrate |
|
B1238-100 |
ApexBio |
100 mg |
EUR 240 |
|
Description: Cidofovir dehydrate is an injectable antiviral medication for the treatment of cytomegalovirus (CMV) retinitis, which suppresses virus replication by selective inhibition of viral DNA synthesis. |
Cidofovir dihydrate |
|
B1238-25 |
ApexBio |
25 mg |
EUR 157.2 |
|
Description: Cidofovir dehydrate is an injectable antiviral medication for the treatment of cytomegalovirus (CMV) retinitis, which suppresses virus replication by selective inhibition of viral DNA synthesis. |
Cidofovir dihydrate |
|
B1238-5.1 |
ApexBio |
10 mM (in 1mL DMSO) |
EUR 129.6 |
|
Description: Cidofovir dehydrate is an injectable antiviral medication for the treatment of cytomegalovirus (CMV) retinitis, which suppresses virus replication by selective inhibition of viral DNA synthesis. |
 Enalaprilat Dihydrate |
|
B2204-10 |
ApexBio |
10 mg |
EUR 164.4 |
|
Description: Enalaprilat is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 1.94 nM. |
Enalaprilat Dihydrate |
|
B2204-100 |
ApexBio |
100 mg |
EUR 351.6 |
|
Description: Enalaprilat is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 1.94 nM. |
Enalaprilat Dihydrate |
|
B2204-50 |
ApexBio |
50 mg |
EUR 235.2 |
|
Description: Enalaprilat is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 1.94 nM. |
 Lisinopril dihydrate |
|
B3290-5.1 |
ApexBio |
10 mM (in 1mL DMSO) |
EUR 129.6 |
|
Description: Lisinopril is a long-acting inhibitor of angiotensin converting enzyme (ACE) with IC50 value of 4.7nM [1].Lisinopril is a lysine analogue of MK 421. |
Lisinopril dihydrate |
|
B3290-50 |
ApexBio |
50 mg |
EUR 153.6 |
|
Description: Lisinopril is a long-acting inhibitor of angiotensin converting enzyme (ACE) with IC50 value of 4.7nM [1].Lisinopril is a lysine analogue of MK 421. |
Lisinopril dihydrate |
|
B3290-S |
ApexBio |
Evaluation Sample |
EUR 97.2 |
|
Description: Lisinopril is a long-acting inhibitor of angiotensin converting enzyme (ACE) with IC50 value of 4.7nM [1].Lisinopril is a lysine analogue of MK 421. |
 Azithromycin Dihydrate |
|
B1669-5.1 |
ApexBio |
10 mM (in 1mL DMSO) |
EUR 184.8 |
|
Description: Azithromycin Dihydrate is an acid stable orally administered macrolide antimicrobial drug, structurally related to erythromycin. |
Azithromycin Dihydrate |
|
B1669-50 |
ApexBio |
50 mg |
EUR 224.4 |
|
Description: Azithromycin Dihydrate is an acid stable orally administered macrolide antimicrobial drug, structurally related to erythromycin. |
 Oxytetracycline Dihydrate |
|
B2001-5.1 |
ApexBio |
10 mM (in 1mL DMSO) |
EUR 129.6 |
|
Description: Oxytetracycline Dihydrate |
Oxytetracycline Dihydrate |
|
B2001-50 |
ApexBio |
50 mg |
EUR 153.6 |
|
Description: Oxytetracycline Dihydrate |
Oxytetracycline Dihydrate |
|
B2001-S |
ApexBio |
Evaluation Sample |
EUR 97.2 |
|
Description: Oxytetracycline Dihydrate |
Cidofovir dihydrate |
|
C202-10MG |
TOKU-E |
10 mg |
EUR 98.4 |
Cidofovir dihydrate |
|
C202-50MG |
TOKU-E |
50 mg |
EUR 262.8 |
Oxytetracycline Dihydrate |
|
O003-10G |
TOKU-E |
10 g |
EUR 85.2 |
Oxytetracycline Dihydrate |
|
O003-50G |
TOKU-E |
50 g |
EUR 279.6 |
 Tauroursodeoxycholate dihydrate |
|
HY-19696B |
MedChemExpress |
50mg |
EUR 142.8 |
 Quercetin Dihydrate |
|
TBZ2533 |
ChemNorm |
20mg |
Ask for price |
 Phlorizin dihydrate |
|
TBZ2935 |
ChemNorm |
20mg |
Ask for price |
Lisinopril dihydrate |
|
B2132-250 |
Biovision |
each |
EUR 352.8 |
Lisinopril dihydrate |
|
B2132-50 |
Biovision |
each |
EUR 157.2 |
 Quercetin, Dihydrate |
|
1773-1000 |
Biovision |
each |
EUR 261.6 |
Quercetin, Dihydrate |
|
1773-250 |
Biovision |
each |
EUR 124.8 |
 Pamidronate Disodium |
|
A2456-5.1 |
ApexBio |
10 mM (in 1mL H2O) |
EUR 129.6 |
|
Description: A bisphosphonate antiresorptive agent and a bone resorption inhibitor. |
Pamidronate Disodium |
|
A2456-50 |
ApexBio |
50 mg |
EUR 153.6 |
|
Description: A bisphosphonate antiresorptive agent and a bone resorption inhibitor. |
 R788 disodium |
|
A8332-10 |
ApexBio |
10 mg |
EUR 309.6 |
|
Description: R788, which is the prodrug of R406, is a potnet and selective Syk inhibitor. The spleen tyrosine kinase (Syk) plays a key role in the signaling of activating Fc receptors and the B-cell receptor (BCR). |
R788 disodium |
|
A8332-100 |
ApexBio |
100 mg |
EUR 1104 |
|
Description: R788, which is the prodrug of R406, is a potnet and selective Syk inhibitor. The spleen tyrosine kinase (Syk) plays a key role in the signaling of activating Fc receptors and the B-cell receptor (BCR). |
R788 disodium |
|
A8332-5 |
ApexBio |
5 mg |
EUR 226.8 |
|
Description: R788, which is the prodrug of R406, is a potnet and selective Syk inhibitor. The spleen tyrosine kinase (Syk) plays a key role in the signaling of activating Fc receptors and the B-cell receptor (BCR). |
R788 disodium |
|
A8332-50 |
ApexBio |
50 mg |
EUR 686.4 |
|
Description: R788, which is the prodrug of R406, is a potnet and selective Syk inhibitor. The spleen tyrosine kinase (Syk) plays a key role in the signaling of activating Fc receptors and the B-cell receptor (BCR). |
R788 disodium |
|
A8332-S |
ApexBio |
Evaluation Sample |
EUR 97.2 |
|
Description: R788, which is the prodrug of R406, is a potnet and selective Syk inhibitor. The spleen tyrosine kinase (Syk) plays a key role in the signaling of activating Fc receptors and the B-cell receptor (BCR). |
 Carbenoxolone disodium |
|
A8389-5.1 |
ApexBio |
10 mM (in 1mL DMSO) |
EUR 129.6 |
|
Description: Carbenoxolone disodium is an inhibitor of 11?-hydroxysteroid dehydrogenase (11?-HSD) [1].11?-HSD is a family of enzymes that regulating the access of glucocorticoids to the steroid receptors. |
Carbenoxolone disodium |
|
A8389-50 |
ApexBio |
50 mg |
EUR 123.6 |
|
Description: Carbenoxolone disodium is an inhibitor of 11?-hydroxysteroid dehydrogenase (11?-HSD) [1].11?-HSD is a family of enzymes that regulating the access of glucocorticoids to the steroid receptors. |
 Etidronate disodium |
|
20-abx181287 |
Abbexa |
|
|
|
|
 Pemetrexed disodium |
|
20-abx184749 |
Abbexa |
|
|
|
|
 Lobenzarit Disodium |
|
20-abx188758 |
Abbexa |
|
|
|
|
 Clodronate Disodium |
|
B1709-50 |
ApexBio |
50 mg |
EUR 153.6 |
|
Description: Clodronate Disodium, a bisphosphonate, is a potent antiosteolytic agent which inhibits bone resorption. |
 Cefotetan Disodium |
|
C117-100MG |
TOKU-E |
100mg |
EUR 112.8 |
Cefotetan Disodium |
|
C117-1G |
TOKU-E |
1g |
EUR 597.6 |
 Temocillin Disodium |
|
T130-100MG |
TOKU-E |
100 mg |
EUR 1183.2 |
Temocillin Disodium |
|
T130-10MG |
TOKU-E |
10 mg |
EUR 322.8 |
 Ticarcillin Disodium |
|
B1536-1G |
Biovision |
each |
EUR 248.4 |
Ticarcillin Disodium |
|
B1536-5G |
Biovision |
each |
EUR 705.6 |
 Pamidronate disodium |
|
1884-250 |
Biovision |
each |
EUR 464.4 |
Pamidronate disodium |
|
1884-50 |
Biovision |
each |
EUR 164.4 |
 Fostamatinib Disodium |
|
1936-1 |
Biovision |
each |
EUR 189.6 |
Fostamatinib Disodium |
|
1936-5 |
Biovision |
each |
EUR 574.8 |
 Carbenicillin disodium |
|
2485-10G |
Biovision |
each |
EUR 705.6 |
Carbenicillin disodium |
|
2485-1G |
Biovision |
each |
EUR 183.6 |
Carbenicillin disodium |
|
2485-5G |
Biovision |
each |
EUR 444 |
-Trehalose dihydrate) D-(+)-Trehalose dihydrate |
|
abx082139-25g |
Abbexa |
25 g |
EUR 260.4 |
|
|
D-(+)-Trehalose dihydrate |
|
abx082202-5g |
Abbexa |
5 g |
EUR 226.8 |
|
|
D-(+)-Trehalose dihydrate |
|
abx082324-5g |
Abbexa |
5 g |
EUR 226.8 |
|
|
 Tetraethylammonium fluoride dihydrate |
|
20-abx184422 |
Abbexa |
-
EUR 343.20
-
EUR 260.40
-
EUR 610.80
|
|
|
|
 Lithium acetate dihydrate |
|
abx184715-500g |
Abbexa |
500 g |
EUR 243.6 |
|
|
 Alizarin complexone dihydrate |
|
20-abx186370 |
Abbexa |
-
EUR 661.20
-
EUR 292.80
-
EUR 477.60
|
|
|
|
 Calcium Levulinate Dihydrate |
|
20-abx186404 |
Abbexa |
-
EUR 861.60
-
EUR 427.20
-
EUR 260.40
|
|
|
|
 1,3,5-Trihydroxybenzene Dihydrate |
|
abx188091-1000g |
Abbexa |
1000 g |
EUR 978 |
|
|
 Amodiaquine dihydrochloride dihydrate |
|
B6134-100 |
ApexBio |
100 mg |
EUR 153.6 |
Amodiaquine dihydrochloride dihydrate |
|
B6134-500 |
ApexBio |
500 mg |
EUR 348 |
 Ondansetron hydrochloride dihydrate |
|
B1204-10 |
ApexBio |
10 mg |
EUR 129.6 |
|
Description: Ondansetron is a serotonin 5-HT3 receptor antagonist used mainly as anantiemetic (to treat nausea and vomiting), often following chemotherapy. |
Ondansetron hydrochloride dihydrate |
|
B1204-5.1 |
ApexBio |
10 mM (in 1mL DMSO) |
EUR 129.6 |
|
Description: Ondansetron is a serotonin 5-HT3 receptor antagonist used mainly as anantiemetic (to treat nausea and vomiting), often following chemotherapy. |
Ondansetron hydrochloride dihydrate |
|
B1204-50 |
ApexBio |
50 mg |
EUR 177.6 |
|
Description: Ondansetron is a serotonin 5-HT3 receptor antagonist used mainly as anantiemetic (to treat nausea and vomiting), often following chemotherapy. |
 Succinylcholine Chloride Dihydrate |
|
B1595-5.1 |
ApexBio |
10 mM (in 1mL DMSO) |
EUR 129.6 |
|
Description: Succinylcholine Chloride Dihydrate is a nicotinic AChR agonist and also acts as a depolarizing neuromuscular blocker. |
 Calcium chloride dihydrate |
|
B7290-1000000 |
ApexBio |
1000 g |
EUR 129.6 |
|
Description: Calcium Chloride is a widely used reagent in the research of biochemistry. Calcium play roles of great importance in physiological function, including signal transmitting, muscle contraction, and maintenance of cell morphology and stability. |
 Barium chloride dihydrate |
|
BC2020 |
Bio Basic |
500g |
EUR 76.7 |
|
|
 Quinine HCl Dihydrate |
|
B2123-10 |
ApexBio |
10 mg |
EUR 153.6 |
|
Description: Quinine HCl Dihydrate |
Quinine HCl Dihydrate |
|
B2123-5.1 |
ApexBio |
10 mM (in 1mL DMSO) |
EUR 151.2 |
|
Description: Quinine HCl Dihydrate |
Quinine HCl Dihydrate |
|
B2123-50 |
ApexBio |
50 mg |
EUR 321.6 |
|
Description: Quinine HCl Dihydrate |
Quinine HCl Dihydrate |
|
B2123-S |
ApexBio |
Evaluation Sample |
EUR 97.2 |
|
Description: Quinine HCl Dihydrate |
 Amiloride HCl dihydrate |
|
B2268-5.1 |
ApexBio |
10 mM (in 1mL DMSO) |
EUR 129.6 |
|
Description: Amiloride HCl dihydrate is a potent epithelial sodium channel blocker. |
Amiloride HCl dihydrate |
|
B2268-50 |
ApexBio |
50 mg |
EUR 153.6 |
|
Description: Amiloride HCl dihydrate is a potent epithelial sodium channel blocker. |
Amiloride HCl dihydrate |
|
B2268-S |
ApexBio |
Evaluation Sample |
EUR 97.2 |
|
Description: Amiloride HCl dihydrate is a potent epithelial sodium channel blocker. |
 Pefloxacin Mesylate Dihydrate |
|
B2291-100 |
ApexBio |
100 mg |
EUR 115.2 |
|
Description: Pefloxacin mesylate dehydrate is a an antibacterial agent and prevents bacterial DNA replication by inhibiting DNA gyrase (topoisomerse) |
Pefloxacin Mesylate Dihydrate |
|
B2291-10000 |
ApexBio |
10 g |
EUR 129.6 |
|
Description: Pefloxacin mesylate dehydrate is a an antibacterial agent and prevents bacterial DNA replication by inhibiting DNA gyrase (topoisomerse) |
Pefloxacin Mesylate Dihydrate |
|
B2291-5.1 |
ApexBio |
10 mM (in 1mL DMSO) |
EUR 129.6 |
|
Description: Pefloxacin mesylate dehydrate is a an antibacterial agent and prevents bacterial DNA replication by inhibiting DNA gyrase (topoisomerse) |
Pefloxacin Mesylate Dihydrate |
|
B2291-50000 |
ApexBio |
50 g |
EUR 268.8 |
|
Description: Pefloxacin mesylate dehydrate is a an antibacterial agent and prevents bacterial DNA replication by inhibiting DNA gyrase (topoisomerse) |
 Ripasudil hydrochloride dihydrate |
|
B2984-1 |
Biovision |
1mg |
EUR 175.2 |
Ripasudil hydrochloride dihydrate |
|
B2984-5 |
Biovision |
5mg |
EUR 514.8 |
 Calcium sulfate, dihydrate |
|
CB0265 |
Bio Basic |
500g |
EUR 82.97 |
|
|
 Calcium chloride, dihydrate |
|
CD0050 |
Bio Basic |
500g |
EUR 80.88 |
|
|
 Pefloxacin mesylate dihydrate |
|
P004-10G |
TOKU-E |
10g |
EUR 94.8 |
Pefloxacin mesylate dihydrate |
|
P004-50G |
TOKU-E |
50g |
EUR 272.4 |
 Oxalic acid, dihydrate |
|
OD0400(D0400) |
Bio Basic |
250g |
EUR 74.62 |
|
|
) Quercetin dihydrate(Sophoretin) |
|
E1KS2347 |
EnoGene |
25mg |
EUR 471.6 |
